Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy

The combined inhibition of histone deacetylases (HDAC) and the proteins of the bromodomain and extraterminal (BET) family have recently shown therapeutic efficacy against melanoma, pancreatic ductal adenocarcinoma, testicular, and lymphoma cancers in murine studies. However, in such studies, the rol...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Badamchi-Zadeh, Alexander, Moynihan, Kelly D., Larocca, Rafael A., Aid, Malika, Provine, Nicholas M., Iampietro, M. Justin, Kinnear, Ekaterina, Penaloza-MacMaster, Pablo, Abbink, Peter, Blass, Eryn, Tregoning, John S., Irvine, Darrell J., Barouch, Dan H.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2018
Assuntos:
Infectious Disease and Host Response
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196294/
https://ncbi.nlm.nih.gov/pubmed/30249811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800885
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