Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus

We have produced Csf1r-deficient rats by homologous recombination in embryonic stem cells. Consistent with the role of Csf1r in macrophage differentiation, there was a loss of peripheral blood monocytes, microglia in the brain, epidermal Langerhans cells, splenic marginal zone macrophages, bone-asso...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Pridans, Clare, Raper, Anna, Davis, Gemma M., Alves, Joana, Sauter, Kristin A., Lefevre, Lucas, Regan, Tim, Meek, Stephen, Sutherland, Linda, Thomson, Alison J., Clohisey, Sara, Bush, Stephen J., Rojo, Rocío, Lisowski, Zofia M., Wallace, Robert, Grabert, Kathleen, Upton, Kyle R., Tsai, Yi Ting, Brown, Deborah, Smith, Lee B., Summers, Kim M., Mabbott, Neil A., Piccardo, Pedro, Cheeseman, Michael T., Burdon, Tom, Hume, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2018
Assuntos:
Immune System Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196293/
https://ncbi.nlm.nih.gov/pubmed/30249809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701783
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