Over-expression of calpastatin attenuates myocardial injury following myocardial infarction by inhibiting endoplasmic reticulum stress

BACKGROUND: Ischemic heart injury activates calpains and endoplasmic reticulum (ER) stress in cardiomyocytes. This study investigated whether over-expression of calpastatin, an endogenous calpain inhibitor, protects the heart against myocardial infarction (MI) by inhibiting ER stress. METHODS: Mice...

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Bibliografische gegevens
Gepubliceerd in:J Thorac Dis
Hoofdauteurs: Li, Shuai, Ma, Jian, Li, Jing-Bo, Lacefield, James C., Jones, Douglas L., Peng, Tian-Qing, Wei, Meng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: AME Publishing Company 2018
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196212/
https://ncbi.nlm.nih.gov/pubmed/30416776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jtd.2018.08.133
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