Randomized Clinical Trial to Assess the Impact of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 on HIV-1 Persistence in Individuals on Effective ART

BACKGROUND: Broadly neutralizing monoclonal antibodies (bnMAbs) may promote clearance of HIV-1-expressing cells through antibody-dependent cell-mediated cytotoxicity. We evaluated the effect of the CD4-binding site bnMAb, VRC01, on measures of HIV-1 persistence in chronically infected individuals. M...

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Dettagli Bibliografici
Pubblicato in:Open Forum Infect Dis
Autori principali: Riddler, Sharon A, Zheng, Lu, Durand, Christine M, Ritz, Justin, Koup, Richard A, Ledgerwood, Julie, Bailer, Robert T, Koletar, Susan L, Eron, Joseph J, Keefer, Michael C, Macatangay, Bernard J C, Cyktor, Joshua C, Mellors, John W
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Major Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195652/
https://ncbi.nlm.nih.gov/pubmed/30364428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy242
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