Population pharmacokinetics analysis of VRC01, an HIV-1 broadly neutralizing monoclonal antibody, in healthy adults

The monoclonal antibody VRC01 targets the CD4 binding site of the human immunodeficiency virus (HIV)-1 envelope. In the clinical study HVTN 104 (NCT02165267), 84 HIV-uninfected adults received multiple-dose intravenous (IV) VRC01 (10, 20, 30 or 40 mg/kg) every 4 or 8 weeks or subcutaneous (SC) VRC01...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Huang, Yunda, Zhang, Lily, Ledgerwood, Julie, Grunenberg, Nicole, Bailer, Robert, Isaacs, Abby, Seaton, Kelly, Mayer, Kenneth H., Capparelli, Edmund, Corey, Larry, Gilbert, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524155/
https://ncbi.nlm.nih.gov/pubmed/28368743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1311435
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