HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

Environmental and genetic risk factors contribute to Parkinson’s Disease (PD) pathogenesis and the associated midbrain dopamine (mDA) neuron loss. Here, we identify early PD pathogenic events by developing methodology that utilizes recent innovations in human pluripotent stem cells (hPSC) and chemic...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Kishinevsky, Sarah, Wang, Tai, Rodina, Anna, Chung, Sun Young, Xu, Chao, Philip, John, Taldone, Tony, Joshi, Suhasini, Alpaugh, Mary L., Bolaender, Alexander, Gutbier, Simon, Sandhu, Davinder, Fattahi, Faranak, Zimmer, Bastian, Shah, Smit K., Chang, Elizabeth, Inda, Carmen, Koren, John, Saurat, Nathalie G., Leist, Marcel, Gross, Steven S., Seshan, Venkatraman E., Klein, Christine, Tomishima, Mark J., Erdjument-Bromage, Hediye, Neubert, Thomas A., Henrickson, Ronald C., Chiosis, Gabriela, Studer, Lorenz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195591/
https://ncbi.nlm.nih.gov/pubmed/30341316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06486-6
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