Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K(+) channel

The cardiac autonomic nervous system (ANS) controls normal atrial electrical function. The cardiac ANS produces various neuropeptides, among which the neurokinins, whose actions on atrial electrophysiology are largely unknown. We here demonstrate that the neurokinin substance-P (Sub-P) activates a n...

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Publicado no:Nat Commun
Main Authors: Veldkamp, Marieke W., Geuzebroek, Guillaume S. C., Baartscheer, Antonius, Verkerk, Arie O., Schumacher, Cees A., Suarez, Gedeon G., Berger, Wouter R., Casini, Simona, van Amersfoorth, Shirley C. M., Scholman, Koen T., Driessen, Antoine H. G., Belterman, Charly N. W., van Ginneken, Antoni C. G., de Groot, Joris R., de Bakker, Jacques M. T., Remme, Carol Ann, Boukens, Bas J., Coronel, Ruben
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195571/
https://ncbi.nlm.nih.gov/pubmed/30341287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06530-5
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