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DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing
R-loops are stable nucleic acid structures that have important physiological functions, but which also pose a significant threat to genomic stability. Increased R-loops cause replication stress and chromosome fragility and have been associated with diseases such as neurodegeneration and cancer. Alth...
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| Publicado no: | Nat Commun |
|---|---|
| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6195550/ https://ncbi.nlm.nih.gov/pubmed/30341290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06677-1 |
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