Unique true predicted neoantigens (TPNAs) correlates with anti-tumor immune control in HCC patients

BACKGROUND: A novel prediction algorithm is needed for the identification of effective tumor associated mutated neoantigens. Only those with no homology to self wild type antigens are true predicted neoantigens (TPNAs) and can elicit an antitumor T cell response, not attenuated by central tolerance....

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Publicat a:J Transl Med
Autors principals: Petrizzo, Annacarmen, Tagliamonte, Maria, Mauriello, Angela, Costa, Valerio, Aprile, Marianna, Esposito, Roberta, Caporale, Andrea, Luciano, Antonio, Arra, Claudio, Tornesello, Maria Lina, Buonaguro, Franco M., Buonaguro, Luigi
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194606/
https://ncbi.nlm.nih.gov/pubmed/30340600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1662-9
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