mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances

The 5′ and 3′ termini of RNA play important roles in many cellular processes. Using Förster resonance energy transfer (FRET), we show that mRNAs and lncRNAs have an intrinsic propensity to fold in the absence of proteins into structures in which the 5′ end and 3′ end are ≤7 nm apart irrespective of...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Lai, Wan-Jung C., Kayedkhordeh, Mohammad, Cornell, Erica V., Farah, Elie, Bellaousov, Stanislav, Rietmeijer, Robert, Salsi, Enea, Mathews, David H., Ermolenko, Dmitri N.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193969/
https://ncbi.nlm.nih.gov/pubmed/30337527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06792-z
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