Anti-Folate Receptor alpha–directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer

PURPOSE: Highly-aggressive triple negative breast cancers (TNBCs) lack validated therapeutic targets and have high risk of metastatic disease. Folate Receptor alpha (FRα) is a central mediator of cell growth regulation that could serve as an important target for cancer therapy. EXPERIMENTAL DESIGN:...

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Pubblicato in:Clin Cancer Res
Autori principali: Cheung, Anthony, Opzoomer, James, Ilieva, Kristina M, Gazinska, Patrycja, Hoffmann, Ricarda M, Mirza, Hasan, Marlow, Rebecca, Francesch-Domenech, Erika, Fittall, Matthew, Dominguez Rodriguez, Diana, Clifford, Angela, Badder, Luned, Patel, Nirmesh, Mele, Silvia, Pellizzari, Giulia, Bax, Heather J, Crescioli, Silvia, Petranyi, Gyula, Larcombe-Young, Daniel, Josephs, Debra H, Canevari, Silvana, Figini, Mariangela, Pinder, Sarah, Nestle, Frank O, Gillett, Cheryl, Spicer, James F, Grigoriadis, Anita, Tutt, Andrew N J, Karagiannis, Sophia N
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193548/
https://ncbi.nlm.nih.gov/pubmed/30068707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0652
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