Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

OBJECTIVE: Serrated colorectal cancer (CRC) accounts for approximately 25% of cases, and includes tumours that are amongst the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the mitogen activated kinase (MAPK) pathway gene, BRAF, and epi...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Lannagan, Tamsin RM, Lee, Young K, Wang, Tongtong, Roper, Jatin, Bettington, Mark L, Fennell, Lochlan, Vrbanac, Laura, Jonavicius, Lisa, Somashekar, Roshini, Gieniec, Krystyna, Yang, Miao, Ng, Jia Q, Suzuki, Nobumi, Ichinose, Mari, Wright, Josephine A, Kobayashi, Hiroki, Putoczki, Tracy L, Hayakawa, Yoku, Leedham, Simon, Abud, Helen E, Yilmaz, Ömer H., Marker, Julie, Klebe, Sonja, Wirapati, Pratyaksha, Mukherjee, Siddhartha, Tejpar, Sabine, Leggett, Barbara A, Whitehall, Vicki LJ, Worthley, Daniel L, Woods, Susan L
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192855/
https://ncbi.nlm.nih.gov/pubmed/29666172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2017-315920
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