Targeted delivery of antisense oligonucleotides to pancreatic β-cells

Antisense oligonucleotide (ASO) silencing of the expression of disease-associated genes is an attractive novel therapeutic approach, but treatments are limited by the ability to deliver ASOs to cells and tissues. Following systemic administration, ASOs preferentially accumulate in liver and kidney....

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Bibliografiska uppgifter
I publikationen:Sci Adv
Huvudupphovsmän: Ämmälä, C., Drury, W. J., Knerr, L., Ahlstedt, I., Stillemark-Billton, P., Wennberg-Huldt, C., Andersson, E.-M., Valeur, E., Jansson-Löfmark, R., Janzén, D., Sundström, L., Meuller, J., Claesson, J., Andersson, P., Johansson, C., Lee, R. G., Prakash, T. P., Seth, P. P., Monia, B. P., Andersson, S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Association for the Advancement of Science 2018
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192685/
https://ncbi.nlm.nih.gov/pubmed/30345352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aat3386
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