Introducing an expanded CAG tract into the huntingtin gene causes a wide spectrum of ultrastructural defects in cultured human cells

Modeling of neurodegenerative diseases in vitro holds great promise for biomedical research. Human cell lines harboring a mutations in disease-causing genes are thought to recapitulate early stages of the development an inherited disease. Modern genome-editing tools allow researchers to create isoge...

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Udgivet i:PLoS One
Main Authors: Morozova, Ksenia N., Suldina, Lyubov A., Malankhanova, Tuyana B., Grigor’eva, Elena V., Zakian, Suren M., Kiseleva, Elena, Malakhova, Anastasia A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192588/
https://ncbi.nlm.nih.gov/pubmed/30332437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204735
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