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An Expanded CAG Repeat in Huntingtin Causes +1 Frameshifting
Maintenance of triplet decoding is crucial for the expression of functional protein because deviations either into the −1 or +1 reading frames are often non-functional. We report here that expression of huntingtin (Htt) exon 1 with expanded CAG repeats, implicated in Huntington pathology, undergoes...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5000095/ https://ncbi.nlm.nih.gov/pubmed/27382061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.744326 |
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