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Synthesis and mechanistic studies of quinolin-chlorobenzothioate derivatives with proteasome inhibitory activity in pancreatic cancer cell lines

Inhibition of proteasome activity blocks the degradation of dysfunctional proteins and induces cancer cell death due to cellular stress. Thus, proteasome inhibitors represent an attractive class of anticancer agents, and bortezomib, carfilzomib and ixazomib have been FDA-approved to treat multiple m...

詳細記述

保存先:
書誌詳細
出版年:Eur J Med Chem
主要な著者: Hu, Shuai, Jin, Yi, Liu, Yanghan, Ljungman, Mats, Neamati, Nouri
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192546/
https://ncbi.nlm.nih.gov/pubmed/30253345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.09.037
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