Discovery of Mitochondrial Transcription Inhibitors Active in Pancreatic Cancer Cells

Mitochondrial dysfunction is a hallmark of cancer cells and targeting cancer mitochondria has emerged as a promising anti-cancer therapy. Previously, we repurposed chlorambucil by conjugating it to a mitochondrial targeting triphenylphosphonium (TPP) group to design Mito-Chlor, a novel agent that ac...

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Vydáno v:ChemMedChem
Hlavní autoři: Chen, Wenmin, Hu, Shuai, Mao, Shuai, Xu, Yibin, Guo, Hui, Li, Haoxi, Paulsen, Michelle T., Chen, Xinde, Ljungman, Mats, Neamati, Nouri
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719573/
https://ncbi.nlm.nih.gov/pubmed/32748543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000494
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