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Discovery of Mitochondrial Transcription Inhibitors Active in Pancreatic Cancer Cells
Mitochondrial dysfunction is a hallmark of cancer cells and targeting cancer mitochondria has emerged as a promising anti-cancer therapy. Previously, we repurposed chlorambucil by conjugating it to a mitochondrial targeting triphenylphosphonium (TPP) group to design Mito-Chlor, a novel agent that ac...
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| Publicado en: | ChemMedChem |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7719573/ https://ncbi.nlm.nih.gov/pubmed/32748543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000494 |
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