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mRNA structure determines specificity of a polyQ-driven phase separation
RNA promotes liquid-liquid phase separation (LLPS) to build membrane-less compartments in cells. How distinct molecular compositions are established and maintained in these liquid compartments is unknown. Here we report that secondary structure allows mRNAs to self-associate and determines if an mRN...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6192030/ https://ncbi.nlm.nih.gov/pubmed/29650703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7432 |
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