mRNA structure determines specificity of a polyQ-driven phase separation

RNA promotes liquid-liquid phase separation (LLPS) to build membrane-less compartments in cells. How distinct molecular compositions are established and maintained in these liquid compartments is unknown. Here we report that secondary structure allows mRNAs to self-associate and determines if an mRN...

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發表在:Science
Main Authors: Langdon, Erin M., Qiu, Yupeng, Niaki, Amirhossein Ghanbari, McLaughlin, Grace A., Weidmann, Chase, Gerbich, Therese M., Smith, Jean A., Crutchley, John M., Termini, Christina M., Weeks, Kevin M., Myong, Sua, Gladfelter, Amy S.
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192030/
https://ncbi.nlm.nih.gov/pubmed/29650703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7432
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