mRNA structure determines specificity of a polyQ-driven phase separation

RNA promotes liquid-liquid phase separation (LLPS) to build membrane-less compartments in cells. How distinct molecular compositions are established and maintained in these liquid compartments is unknown. Here we report that secondary structure allows mRNAs to self-associate and determines if an mRN...

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Publicat a:Science
Autors principals: Langdon, Erin M., Qiu, Yupeng, Niaki, Amirhossein Ghanbari, McLaughlin, Grace A., Weidmann, Chase, Gerbich, Therese M., Smith, Jean A., Crutchley, John M., Termini, Christina M., Weeks, Kevin M., Myong, Sua, Gladfelter, Amy S.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192030/
https://ncbi.nlm.nih.gov/pubmed/29650703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7432
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