mRNA structure determines specificity of a polyQ-driven phase separation

RNA promotes liquid-liquid phase separation (LLPS) to build membrane-less compartments in cells. How distinct molecular compositions are established and maintained in these liquid compartments is unknown. Here we report that secondary structure allows mRNAs to self-associate and determines if an mRN...

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Gepubliceerd in:Science
Hoofdauteurs: Langdon, Erin M., Qiu, Yupeng, Niaki, Amirhossein Ghanbari, McLaughlin, Grace A., Weidmann, Chase, Gerbich, Therese M., Smith, Jean A., Crutchley, John M., Termini, Christina M., Weeks, Kevin M., Myong, Sua, Gladfelter, Amy S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192030/
https://ncbi.nlm.nih.gov/pubmed/29650703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7432
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