mRNA structure determines specificity of a polyQ-driven phase separation

RNA promotes liquid-liquid phase separation (LLPS) to build membrane-less compartments in cells. How distinct molecular compositions are established and maintained in these liquid compartments is unknown. Here we report that secondary structure allows mRNAs to self-associate and determines if an mRN...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Langdon, Erin M., Qiu, Yupeng, Niaki, Amirhossein Ghanbari, McLaughlin, Grace A., Weidmann, Chase, Gerbich, Therese M., Smith, Jean A., Crutchley, John M., Termini, Christina M., Weeks, Kevin M., Myong, Sua, Gladfelter, Amy S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192030/
https://ncbi.nlm.nih.gov/pubmed/29650703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7432
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