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Coupling between conformational dynamics and catalytic function at the active site of the lead-dependent ribozyme
In common with other self-cleaving RNAs, the lead-dependent ribozyme (leadzyme) undergoes dynamic fluctuations to a chemically activated conformation. We explored the connection between conformational dynamics and self-cleavage function in the leadzyme using a combination of NMR spin-relaxation anal...
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| 發表在: | RNA |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cold Spring Harbor Laboratory Press
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6191710/ https://ncbi.nlm.nih.gov/pubmed/30111534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.067579.118 |
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