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Coupling between Catalytic Site and Collective Dynamics: A Requirement for Mechanochemical Activity of Enzymes
Growing evidence supports the view that enzymatic activity results from a subtle interplay between chemical kinetics and molecular motions. A systematic analysis is performed here to delineate the type and level of coupling between catalysis and conformational mechanics. The dynamics of a set of 98...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1489920/ https://ncbi.nlm.nih.gov/pubmed/15939021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2005.03.015 |
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