Dual inhibition of DNA and histone methyltransferases increases viral mimicry in ovarian cancer cells

Ovarian cancer ranks as the most deadly gynecologic cancer and there is an urgent need to develop more effective therapies. Previous studies have shown that G9A, a histone methyltransferase that catalyzes mono- and di-methylation of histone H3 lysine9, is highly expressed in ovarian cancer tumors, a...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Liu, Minmin, Thomas, Stacey L., DeWitt, Ashley K., Zhou, Wanding, Madaj, Zachary B., Ohtani, Hitoshi, Baylin, Stephen B., Liang, Gangning, Jones, Peter A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191339/
https://ncbi.nlm.nih.gov/pubmed/30185548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3953
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