Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories. Here we introduce a machine-learning technique—Subtype and Stage Inference (SuStaIn)—able to...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Young, Alexandra L, Marinescu, Razvan V, Oxtoby, Neil P, Bocchetta, Martina, Yong, Keir, Firth, Nicholas C, Cash, David M, Thomas, David L, Dick, Katrina M, Cardoso, Jorge, van Swieten, John, Borroni, Barbara, Galimberti, Daniela, Masellis, Mario, Tartaglia, Maria Carmela, Rowe, James B, Graff, Caroline, Tagliavini, Fabrizio, Frisoni, Giovanni B, Laforce, Robert, Finger, Elizabeth, de Mendonça, Alexandre, Sorbi, Sandro, Warren, Jason D, Crutch, Sebastian, Fox, Nick C, Ourselin, Sebastien, Schott, Jonathan M, Rohrer, Jonathan D, Alexander, Daniel C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189176/
https://ncbi.nlm.nih.gov/pubmed/30323170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05892-0
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