NBCe1 Na(+)-HCO3(-) cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo

AIM: To investigate the hypothesis that cardiomyocyte-specific loss of the electrogenic NBCe1 Na(+)-HCO(3)(-) cotransporter is cardioprotective during in vivo ischemia-reperfusion (IR) injury. METHODS: An NBCe1 (Slc4a4 gene) conditional knockout mouse (KO) model was prepared by gene targeting. Cardi...

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Vydáno v:World J Cardiol
Hlavní autoři: Vairamani, Kanimozhi, Prasad, Vikram, Wang, Yigang, Huang, Wei, Chen, Yinhua, Medvedovic, Mario, Lorenz, John N, Shull, Gary E
Médium: Artigo
Jazyk:Inglês
Vydáno: Baishideng Publishing Group Inc 2018
Témata:
Basic Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189072/
https://ncbi.nlm.nih.gov/pubmed/30344957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4330/wjc.v10.i9.97
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