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Loss of NHE1 activity leads to reduced oxidative stress in heart and mitigates high-fat diet-induced myocardial stress

Acute inhibition of the NHE1 Na(+)/H(+) exchanger protects against ischemia-reperfusion injury and chronic inhibition attenuates development of cardiac hypertrophy and failure. To determine the cardiac effects of chronic inhibition of NHE1 under non-pathological conditions we used NHE1-null mice as...

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Autors principals: Prasad, Vikram, Lorenz, John N., Miller, Marian L., Vairamani, Kanimozhi, Nieman, Michelle L., Wang, Yigang, Shull, Gary E.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883452/
https://ncbi.nlm.nih.gov/pubmed/24080184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.09.013
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