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Secretory Pathway Stress Responses as Possible Mechanisms of Disease Involving Golgi Ca(2+) Pump Dysfunction
In mammalian tissues, uptake of Ca(2+) and Mn(2+) by Golgi membranes is mediated by the secretory pathway Ca(2+)- ATPases, SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes. Loss of one copy of the ATP2C1 gene, which causes SPCA1 haploinsufficiency, leads to squamous cell tumors of keratinized...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3338190/ https://ncbi.nlm.nih.gov/pubmed/21674634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biof.141 |
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