Deficiency of ATP2C1, a Golgi Ion Pump, Induces Secretory Pathway Defects in Endoplasmic Reticulum (ER)-associated Degradation and Sensitivity to ER Stress

Relatively few clues have been uncovered to elucidate the cell biological role(s) of mammalian ATP2C1 encoding an inwardly directed secretory pathway Ca(2+)/Mn(2+) pump that is ubiquitously expressed. Deficiency of ATP2C1 results in a human disease (Hailey-Hailey), which primarily affects keratinocy...

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Autores principales: Ramos-Castañeda, Jose, Park, Young-nam, Liu, Ming, Hauser, Karin, Rudolph, Hans, Shull, Gary E., Jonkman, Marcel F., Mori, Kazutoshi, Ikeda, Shigaku, Ogawa, Hideoki, Arvan, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: 2004
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527542/
https://ncbi.nlm.nih.gov/pubmed/15623514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M413243200
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