Maitotoxin converts the plasmalemmal Ca(2+) pump into a Ca(2+)-permeable nonselective cation channel

Maitotoxin (MTX) activates Ca(2+)-permeable nonselective cation channels and causes a dramatic increase in cytosolic free Ca(2+) concentration ([Ca(2+)](i)) in every cell examined to date, but the molecular identity of the channels involved remains unknown. A clue came from studies of a structurally...

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Detalhes bibliográficos
Main Authors: Sinkins, William G., Estacion, Mark, Prasad, Vikram, Goel, Monu, Shull, Gary E., Kunze, Diana L., Schilling, William P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Membrane Transporters, Ion Channels, and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793065/
https://ncbi.nlm.nih.gov/pubmed/19794142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00252.2009
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