Sensitivity of CD3/CD28-stimulated versus non-stimulated lymphocytes to ionizing radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation response

Activation of T cells, a major fraction of peripheral blood lymphocytes (PBLCS), is essential for the immune response. Genotoxic stress resulting from ionizing radiation (IR) and chemical agents, including anticancer drugs, has serious impact on T cells and, therefore, on the immune status. Here we...

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Udgivet i:Cell Death Dis
Main Authors: Heylmann, Daniel, Badura, Jennifer, Becker, Huong, Fahrer, Jörg, Kaina, Bernd
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189042/
https://ncbi.nlm.nih.gov/pubmed/30323167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1095-7
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