Human Monocytes Undergo Excessive Apoptosis following Temozolomide Activating the ATM/ATR Pathway While Dendritic Cells and Macrophages Are Resistant

Immunodeficiency is a severe therapy-limiting side effect of anticancer chemotherapy resulting from sensitivity of immunocompetent cells to DNA damaging agents. A central role in the immune system is played by monocytes that differentiate into macrophages and dendritic cells (DCs). In this study we...

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Autores principales: Bauer, Martina, Goldstein, Michael, Heylmann, Daniel, Kaina, Bernd
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386965/
https://ncbi.nlm.nih.gov/pubmed/22768182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039956
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