Dynamic acetylation of cytosolic phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions

Cytosolic phosphoenolpyruvate carboxykinase (PCK1) is considered a gluconeogenic enzyme; however, its metabolic functions and regulatory mechanisms beyond gluconeogenesis are poorly understood. Here we describe that dynamic acetylation of PCK1 interconverts the enzyme between gluconeogenic and anapl...

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Bibliografiske detaljer
Udgivet i:Mol Cell
Main Authors: Latorre-Muro, Pedro, Baeza, Josue, Armstrong, Eric A., Hurtado-Guerrero, Ramón, Corzana, Francisco, Wu, Lindsay E., Sinclair, David A., López-Buesa, Pascual, Carrodeguas, José A., Denu, John M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188669/
https://ncbi.nlm.nih.gov/pubmed/30193097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.07.031
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