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Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity

Acetylation is known to regulate the activity of cytosolic phosphoenolpyruvate carboxykinase (PCK1), a key enzyme in gluconeogenesis, by promoting the reverse reaction of the enzyme (converting phosphoenolpyruvate to oxaloacetate). It is also known that the histone acetyltransferase p300 can induce...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Latorre-Muro, Pedro, Baeza, Josue, Hurtado-Guerrero, Ramon, Hicks, Thomas, Delso, Ignacio, Hernández-Ruiz, Cristina, Velázquez-Campoy, Adrian, Lawton, Alexis J., Angulo, Jesús, Denu, John M., Carrodeguas, José A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948413/
https://ncbi.nlm.nih.gov/pubmed/33334880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015103
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