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Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice
RAP1, a component of the telomere-protective shelterin complex, has been shown to have both telomeric and non-telomeric roles. In the liver, RAP1 is involved in the regulation of metabolic transcriptional programs. RAP1-deficient mice develop obesity and hepatic steatosis, these phenotypes being mor...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6187989/ https://ncbi.nlm.nih.gov/pubmed/30307978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204909 |
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