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Structure–function analyses reveal a triple β-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design

The cardioprotective vasodilator peptide adrenomedullin 2/intermedin (AM2/IMD) and the related adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) signal through three heterodimeric receptors comprising the calcitonin receptor–like class B G protein–coupled receptor (CLR) and a variable r...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Roehrkasse, Amanda M., Booe, Jason M., Lee, Sang-Min, Warner, Margaret L., Pioszak, Augen A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187615/
https://ncbi.nlm.nih.gov/pubmed/30139742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005062
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