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Probing the Mechanism of Receptor Activity–Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists
Binding of the vasodilator peptides adrenomedullin (AM) and calcitonin gene–related peptide (CGRP) to the class B G protein–coupled receptor calcitonin receptor–like receptor (CLR) is modulated by receptor activity–modifying proteins (RAMPs). RAMP1 favors CGRP, whereas RAMP2 and RAMP3 favor AM. Crys...
Tallennettuna:
| Julkaisussa: | Mol Pharmacol |
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| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5832325/ https://ncbi.nlm.nih.gov/pubmed/29363552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110916 |
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