Probing the Mechanism of Receptor Activity–Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists

Binding of the vasodilator peptides adrenomedullin (AM) and calcitonin gene–related peptide (CGRP) to the class B G protein–coupled receptor calcitonin receptor–like receptor (CLR) is modulated by receptor activity–modifying proteins (RAMPs). RAMP1 favors CGRP, whereas RAMP2 and RAMP3 favor AM. Crys...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Booe, Jason M., Warner, Margaret L., Roehrkasse, Amanda M., Hay, Debbie L., Pioszak, Augen A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832325/
https://ncbi.nlm.nih.gov/pubmed/29363552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110916
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