Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1

[Image: see text] The orphan nuclear receptor Liver Receptor Homologue-1 (LRH-1) is an emerging drug target for metabolic disorders. The most effective known LRH-1 modulators are phospholipids or synthetic hexahydropentalene compounds. While both classes have micromolar efficacy, they target differe...

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Udgivet i:ACS Med Chem Lett
Main Authors: Flynn, Autumn R., Mays, Suzanne G., Ortlund, Eric A., Jui, Nathan T.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187417/
https://ncbi.nlm.nih.gov/pubmed/30344916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00361
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