SAR by kinetics for drug discovery in protein misfolding diseases

To develop effective therapeutic strategies for protein misfolding diseases, a promising route is to identify compounds that inhibit the formation of protein oligomers. To achieve this goal, we report a structure−activity relationship (SAR) approach based on chemical kinetics to estimate quantitativ...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Chia, Sean, Habchi, Johnny, Michaels, Thomas C. T., Cohen, Samuel I. A., Linse, Sara, Dobson, Christopher M., Knowles, Tuomas P. J., Vendruscolo, Michele
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2018
Aiheet:
Physical Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187117/
https://ncbi.nlm.nih.gov/pubmed/30257937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807884115
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