Transient Retrovirus-Based CRISPR/Cas9 All-in-One Particles for Efficient, Targeted Gene Knockout

The recently discovered CRISPR/Cas9 system is widely used in basic research and is a useful tool for disease modeling and gene editing therapies. However, long-term expression of DNA-modifying enzymes can be associated with cytotoxicity and is particularly unwanted in clinical gene editing strategie...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Knopp, Yvonne, Geis, Franziska K., Heckl, Dirk, Horn, Stefan, Neumann, Thomas, Kuehle, Johannes, Meyer, Janine, Fehse, Boris, Baum, Christopher, Morgan, Michael, Meyer, Johann, Schambach, Axel, Galla, Melanie
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187057/
https://ncbi.nlm.nih.gov/pubmed/30317165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.09.006
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