AB083. TEW-7197, a novel orally bioavailable activin receptor-like kinase 5 inhibitor, promotes regression of fibrotic plaque in a rat model of Peyronie’s disease

BACKGROUND: To examine therapeutic effect of TEW-7197, a novel small molecule inhibitor of activin receptor-like kinase 5 (ALK5), in an animal model of Peyronie’s disease (PD) and to determine mechanisms by which TEW-7197 ameliorates fibrotic responses in primary fibroblasts derived from human PD pl...

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Bibliografische gegevens
Gepubliceerd in:Transl Androl Urol
Hoofdauteurs: Song, Kang-Moon, Choi, Min Ji, Ghatak, Kalyan, Minh, Nguyen Nhat, Kwon, Mi-Hye, Ock, Jiyeon, Yin, Guo Nan, Ryu, Ji-Kan, Suh, Jun-Kyu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: AME Publishing Company 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6186741/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tau.2018.AB083
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