Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications

BACKGROUND: Mammalian cells express a single functional heparanase, an endoglycosidase that cleaves heparan sulfate and thereby promotes tumor metastasis, angiogenesis, and inflammation. Malignant mesothelioma is highly aggressive and has a poor prognosis because of the lack of markers for early dia...

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Detalhes bibliográficos
Publicado no:J Natl Cancer Inst
Main Authors: Barash, Uri, Lapidot, Moshe, Zohar, Yaniv, Loomis, Cynthia, Moreira, Andre, Feld, Sari, Goparaju, Chandra, Yang, Haining, Hammond, Edward, Zhang, Ganlin, Li, Jin-Ping, Ilan, Neta, Nagler, Arnon, Pass, Harvey I, Vlodavsky, Israel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6186523/
https://ncbi.nlm.nih.gov/pubmed/29579286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djy032
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