Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-beta Aggregation

Peptidic-nanodiscs are useful membrane-mimetic tools for structural and functional studies of membrane proteins, and membrane interacting peptides including amyloids. Here, we demonstrate anti-amyloidogenic activities of a nanodisc-forming 18-residue peptide (denoted as 4F), both in lipid-bound and...

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Bibliographic Details
Published in:J Mol Biol
Main Authors: Sahoo, Bikash Ranjan, Genjo, Takuya, Cox, Sarah J., Stoddard, Andrea K., Anantharamaiah, G. M., Fierke, Carol, Ramamoorthy, Ayyalusamy
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6186505/
https://ncbi.nlm.nih.gov/pubmed/30170005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.08.018
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