Alzheimer’s Amyloid-Beta Intermediates Generated by Polymer-Nanodiscs

Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (~10 nm) and macro-nanodiscs (>15 nm) are used to study Aβ(1–40) aggregation. We demonstrate that PMA-nanodiscs form a ternary association with Aβ and regulate its aggregation kinetics by trapping intermediates. Results demonstrating reduce...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Chem Commun (Camb)
Päätekijät: Sahoo, Bikash R., Genjo, Takuya, Bekier, Michael, Cox, Sarah J., Stoddard, Andrea K., Ivanova, Magdalena, Yasuhara, Kazuma, Fierke, Carol A., Wang, Yanzhuang, Ramamoorthy, Ayyalusamy
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6247814/
https://ncbi.nlm.nih.gov/pubmed/30379172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc07921h
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