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Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington’s disease
In Huntington disease (HD), an expanded polyglutamine (polyQ > 37) sequence within huntingtin (htt) exon1 leads to enhanced disease risk. It has proved difficult, however, to determine whether the toxic form generated by polyQ expansion is a misfolded or avid-binding monomer, an α-helix-rich olig...
Shranjeno v:
| izdano v: | Neurobiol Dis |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6186178/ https://ncbi.nlm.nih.gov/pubmed/30171891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.08.019 |
| Oznake: |
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