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Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington’s disease

In Huntington disease (HD), an expanded polyglutamine (polyQ > 37) sequence within huntingtin (htt) exon1 leads to enhanced disease risk. It has proved difficult, however, to determine whether the toxic form generated by polyQ expansion is a misfolded or avid-binding monomer, an α-helix-rich olig...

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Détails bibliographiques
Publié dans:Neurobiol Dis
Auteurs principaux: Drombosky, Kenneth W., Rode, Sascha, Kodali, Ravi, Jacob, Tija C., Palladino, Michael J., Wetzel, Ronald
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6186178/
https://ncbi.nlm.nih.gov/pubmed/30171891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.08.019
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