ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup

The commonly mutated genes in pancreatic neuroendocrine tumors (PanNETs) are ATRX, DAXX, and MEN1. We genotyped 64 PanNETs and found 58% carry ATRX, DAXX, and MEN1 mutations (A-D-M mutant PanNETs) and this correlates with a worse clinical outcome than tumors carrying the wild-type alleles of all thr...

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Pubblicato in:Nat Commun
Autori principali: Chan, Chang S., Laddha, Saurabh V., Lewis, Peter W., Koletsky, Matthew S., Robzyk, Kenneth, Da Silva, Edaise, Torres, Paula J., Untch, Brian R., Li, Janet, Bose, Promita, Chan, Timothy A., Klimstra, David S., Allis, C. David, Tang, Laura H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6185985/
https://ncbi.nlm.nih.gov/pubmed/30315258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06498-2
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