Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions

The turnover of brain proteins is critical for organism survival, and its perturbations are linked to pathology. Nevertheless, protein lifetimes have been difficult to obtain in vivo. They are readily measured in vitro by feeding cells with isotopically labeled amino acids, followed by mass spectrom...

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Publicado en:Nat Commun
Main Authors: Fornasiero, Eugenio F., Mandad, Sunit, Wildhagen, Hanna, Alevra, Mihai, Rammner, Burkhard, Keihani, Sarva, Opazo, Felipe, Urban, Inga, Ischebeck, Till, Sakib, M. Sadman, Fard, Maryam K., Kirli, Koray, Centeno, Tonatiuh Pena, Vidal, Ramon O., Rahman, Raza-Ur, Benito, Eva, Fischer, André, Dennerlein, Sven, Rehling, Peter, Feussner, Ivo, Bonn, Stefan, Simons, Mikael, Urlaub, Henning, Rizzoli, Silvio O.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6185916/
https://ncbi.nlm.nih.gov/pubmed/30315172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06519-0
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