Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage

Sensitivity and resistance of cells to platinum drug chemotherapy are to a large extent determined by activity of the DNA damage response (DDR). Combining chemotherapy with inhibition of specific DDR pathways could therefore improve treatment efficacy. Multiple DDR pathways have been implicated in r...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Slyskova, Jana, Sabatella, Mariangela, Ribeiro-Silva, Cristina, Stok, Colin, Theil, Arjan F, Vermeulen, Wim, Lans, Hannes
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182164/
https://ncbi.nlm.nih.gov/pubmed/30137419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky764
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