Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress

Anabolism and catabolism are tightly regulated according to the cellular energy supply. Upon energy stress, ribosomal RNA (rRNA) biogenesis is inhibited, and autophagy is induced. However, the mechanism linking rRNA biogenesis and autophagy is unclear. Here, we demonstrate that the nucleolar protein...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Liu, Xiaofeng, Cai, Shiying, Zhang, Chunfeng, Liu, Zhenzhen, Luo, Jianyuan, Xing, Baocai, Du, Xiaojuan
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182161/
https://ncbi.nlm.nih.gov/pubmed/30165671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky777
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