A lipidated bi-epitope vaccine comprising of MHC-I and MHC-II binder peptides elicits protective CD4 T cell and CD8 T cell immunity against Mycobacterium tuberculosis

BACKGROUND: The clinical trials conducted at Chingleput India suggest that BCG fails to protect against tuberculosis (TB) in TB-endemic population. Recent studies advocate that non-tuberculous mycobacteria and latent Mycobacterium tuberculosis (Mtb) infection interferes in the antigen processing and...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Rai, Pradeep K., Chodisetti, Sathi Babu, Maurya, Sudeep K., Nadeem, Sajid, Zeng, Weiguang, Janmeja, Ashok K., Jackson, David C., Agrewala, Javed N.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180631/
https://ncbi.nlm.nih.gov/pubmed/30305097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1653-x
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